5j2s

Structural highlights

Function

[KRBBA_RAT] Receptor for CLEC2D/OCIL. Ligand-binding contributes to inhibition of cytotoxic natural killer (NK) cells. May mediate MHC class I-independent 'missing-self' recognition of allografts, tumor cells and virus-infected cells.^{[1] [2]}

References

1. ↑ Kveberg L, Back CJ, Dai KZ, Inngjerdingen M, Rolstad B, Ryan JC, Vaage JT, Naper C. The novel inhibitory NKR-P1C receptor and Ly49s3 identify two complementary, functionally distinct NK cell subsets in rats. J Immunol. 2006 Apr 1;176(7):4133-40. PMID:16547249
2. ↑ Voigt S, Mesci A, Ettinger J, Fine JH, Chen P, Chou W, Carlyle JR. Cytomegalovirus evasion of innate immunity by subversion of the NKR-P1B:Clr-b missing-self axis. Immunity. 2007 May;26(5):617-27. doi: 10.1016/j.immuni.2007.03.013. Epub 2007 Apr, 26. PMID:17462921 doi:http://dx.doi.org/10.1016/j.immuni.2007.03.013