6q83

Structural highlights

Function

[KA122_YEAST] Nuclear transport factor (karyopherin) involved in protein transport between the cytoplasm and nucleoplasm. Required for the nuclear import of the complex composed the large subunit (TOA1) and the small subunit (TOA2) of the general transcription factor IIA (TFIIA). Required for the nuclear import of the RNR2-RNR4 heterodimer, also called beta-beta' subunit, which corresponds to the small subunit of the ribonucleotide reductase (RNR). May play a role in regulation of pleiotropic drug resistance.^{[1] [2] [3] [4]} [UBC9_YEAST] E2 ubiquitin-like--protein ligase mediating SUMO/Smt3 attachment to septins and PCNA. Seems to be involved in degradation of S- (CLB5) and M-phase cyclins (CLB2).^{[5] [6]}

References

1. ↑ Titov AA, Blobel G. The karyopherin Kap122p/Pdr6p imports both subunits of the transcription factor IIA into the nucleus. J Cell Biol. 1999 Oct 18;147(2):235-46. PMID:10525531
2. ↑ Zhang Z, An X, Yang K, Perlstein DL, Hicks L, Kelleher N, Stubbe J, Huang M. Nuclear localization of the Saccharomyces cerevisiae ribonucleotide reductase small subunit requires a karyopherin and a WD40 repeat protein. Proc Natl Acad Sci U S A. 2006 Jan 31;103(5):1422-7. doi:, 10.1073/pnas.0510516103. Epub 2006 Jan 23. PMID:16432237 doi:http://dx.doi.org/10.1073/pnas.0510516103
3. ↑ Chen WN, Balzi E, Capieaux E, Choder M, Goffeau A. The DNA sequencing of the 17 kb HindIII fragment spanning the LEU1 and ATE1 loci on chromosome VII from Saccharomyces cerevisiae reveals the PDR6 gene, a new member of the genetic network controlling pleiotropic drug resistance. Yeast. 1991 Apr;7(3):287-99. doi: 10.1002/yea.320070311. PMID:1882553 doi:http://dx.doi.org/10.1002/yea.320070311
4. ↑ Wu X, Huang M. Dif1 controls subcellular localization of ribonucleotide reductase by mediating nuclear import of the R2 subunit. Mol Cell Biol. 2008 Dec;28(23):7156-67. doi: 10.1128/MCB.01388-08. Epub 2008 Oct , 6. PMID:18838542 doi:http://dx.doi.org/10.1128/MCB.01388-08
5. ↑ Johnson ES, Blobel G. Ubc9p is the conjugating enzyme for the ubiquitin-like protein Smt3p. J Biol Chem. 1997 Oct 24;272(43):26799-802. PMID:9341106
6. ↑ Johnson ES, Gupta AA. An E3-like factor that promotes SUMO conjugation to the yeast septins. Cell. 2001 Sep 21;106(6):735-44. PMID:11572779