Peroxiomal multifunctional enzyme type 2 (MFE-2) is a three part enzyme used in beta oxidation of very-long-chain fatty acids. The enzyme works the second and third steps in the peroxisomal beta oxidation. The three parts of the enzyme include (3R)-hydroxyacyl-CoA dehydrogenase ((3R)-dehydrogenase), sterol carrier protein 2-like units (SCP-2L), and 2-enoyl-CoA hydratase (hydratase 2). MFE-2 is a two-domain structure with a C-domain complete hot-dog fold around the active site, and a N-domain fold housing the cavity for the aliphatic acyl part of the substrate molecule. MFE-2 is essential in the breakdown of very-long-chain fatty acids, as well as bile acid synthesis.
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Structural highlights
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