Structural highlights
4u4p is a 2 chain structure with sequence from Human. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
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| Gene: | SMC2, CAPE, SMC2L1, PRO0324 (HUMAN), SMC4, CAPC, SMC4L1 (HUMAN) |
| Resources: | FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT |
Function
[SMC2_HUMAN] Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.[1] [SMC4_HUMAN] Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.[2]
References
- ↑ Kimura K, Cuvier O, Hirano T. Chromosome condensation by a human condensin complex in Xenopus egg extracts. J Biol Chem. 2001 Feb 23;276(8):5417-20. Epub 2001 Jan 2. PMID:11136719 doi:http://dx.doi.org/10.1074/jbc.C000873200
- ↑ Kimura K, Cuvier O, Hirano T. Chromosome condensation by a human condensin complex in Xenopus egg extracts. J Biol Chem. 2001 Feb 23;276(8):5417-20. Epub 2001 Jan 2. PMID:11136719 doi:http://dx.doi.org/10.1074/jbc.C000873200
