Crystal Structure of Flavin Dependent Thymidylate Synthase, Thy1, from Thermus thermophilus having an Extra C Terminal Domain
Professor Gota Kawai [1]
Molecular Tour
Thy1 is an enzyme which catalyze the reaction to produce thymidine monophosphate from deoxyuridine monophosphate. The Thy1 from Thermus thermophilus was found , TtThy1, have an extra domain with 48 amino acids at the C terminal. BLAST search showed that the CTD domain exists only for Thy1 from Thermus, Marinithermus, Oceanithermus and Truepera. The structure of TtThy1 was determined by X-ray crystallography. is similar to the known structures and the CTD was found to consist of 3 alpha-helices and a beta-strand.
References
- ↑ doi: https://dx.doi.org/10.1107/S2053230X19007192
