Structural highlights
Function
[ATGA1_HUMAN] Autophagy factor required for autophagosome formation. Stabilizes ATG13, protecting it from proteasomal degradation.[1] [2]
Publication Abstract from PubMed
ATG101 is an essential component of the ULK complex responsible for initiating cellular autophagy in mammalian cells; its 3-dimensional structure and molecular function, however, are currently unclear. Here we present the X-ray structure of human ATG101. The protein displays an open HORMA domain fold. Both structural properties and biophysical evidence indicate that ATG101 is locked in this conformation, in contrast to the prototypical HORMA domain protein MAD2. Moreover, we discuss a potential mode of dimerization with ATG13 as a fundamental aspect of ATG101 function.
The mammalian autophagy initiator complex contains two HORMA domain proteins.,Michel M, Schwarten M, Decker C, Nagel-Steger L, Willbold D, Weiergraber OH Autophagy. 2015 Aug 3:0. PMID:26236954[3]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
See Also
References
- ↑ Mercer CA, Kaliappan A, Dennis PB. A novel, human Atg13 binding protein, Atg101, interacts with ULK1 and is essential for macroautophagy. Autophagy. 2009 Jul;5(5):649-62. Epub 2009 Jul 20. PMID:19287211
- ↑ Hosokawa N, Sasaki T, Iemura S, Natsume T, Hara T, Mizushima N. Atg101, a novel mammalian autophagy protein interacting with Atg13. Autophagy. 2009 Oct;5(7):973-9. Epub 2009 Oct 18. PMID:19597335
- ↑ Michel M, Schwarten M, Decker C, Nagel-Steger L, Willbold D, Weiergraber OH. The mammalian autophagy initiator complex contains two HORMA domain proteins. Autophagy. 2015 Aug 3:0. PMID:26236954 doi:http://dx.doi.org/10.1080/15548627.2015.1076605
