6bnm

Structural highlights

Function

[PREX2_HUMAN] Functions as a RAC1 guanine nucleotide exchange factor (GEF), activating Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein. Mediates the activation of RAC1 in a PI3K-dependent manner. May be an important mediator of Rac signaling, acting directly downstream of both G protein-coupled receptors and phosphoinositide 3-kinase.^{[1] [2] [3]}

References

1. ↑ Rosenfeldt H, Vazquez-Prado J, Gutkind JS. P-REX2, a novel PI-3-kinase sensitive Rac exchange factor. FEBS Lett. 2004 Aug 13;572(1-3):167-71. PMID:15304342 doi:http://dx.doi.org/10.1016/j.febslet.2004.06.097
2. ↑ Donald S, Hill K, Lecureuil C, Barnouin R, Krugmann S, John Coadwell W, Andrews SR, Walker SA, Hawkins PT, Stephens LR, Welch HC. P-Rex2, a new guanine-nucleotide exchange factor for Rac. FEBS Lett. 2004 Aug 13;572(1-3):172-6. doi: 10.1016/j.febslet.2004.06.096. PMID:15304343 doi:http://dx.doi.org/10.1016/j.febslet.2004.06.096
3. ↑ Joseph RE, Norris FA. Substrate specificity and recognition is conferred by the pleckstrin homology domain of the Dbl family guanine nucleotide exchange factor P-Rex2. J Biol Chem. 2005 Jul 29;280(30):27508-12. Epub 2005 May 16. PMID:15897194 doi:http://dx.doi.org/M412495200