Structural highlights
6buq is a 4 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
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| Ligands: | , , , , , , |
| Activity: | Cyanuric acid amidohydrolase, with EC number 3.5.2.15 |
| Resources: | FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT |
Function
[CAH_MOOTA] Responsible for the hydrolysis of cyanuric acid, an intermediate formed during catabolism of s-triazine based compounds in herbicides such as atrazine and polymers such as melamine. Catalyzes the hydrolytic opening of the s-triazine ring of cyanuric acid (2,4,6-trihydroxy-s-triazine) to yield carbon dioxide and carboxybiuret, which spontaneously decarboxylates to biuret.[HAMAP-Rule:MF_01989][1] [2]
References
- ↑ Li Q, Seffernick JL, Sadowsky MJ, Wackett LP. Thermostable cyanuric acid hydrolase from Moorella thermoacetica ATCC 39073. Appl Environ Microbiol. 2009 Nov;75(22):6986-91. doi: 10.1128/AEM.01605-09. Epub , 2009 Sep 18. PMID:19767460 doi:http://dx.doi.org/10.1128/AEM.01605-09
- ↑ Peat TS, Balotra S, Wilding M, Hartley CJ, Newman J, Scott C. High resolution X-ray structures of two functionally distinct members of the cyclic amide hydrolase (CyAH) family of Toblerone fold enzymes. Appl Environ Microbiol. 2017 Feb 24. pii: AEM.03365-16. doi:, 10.1128/AEM.03365-16. PMID:28235873 doi:http://dx.doi.org/10.1128/AEM.03365-16
