Structural highlights
Function
[CO13_CONST] Omega-conotoxins act at presynaptic membranes, they bind and block voltage-gated calcium channels (Cav). This peptide selectively targets N-type voltage-gated calcium channels (Cav2.2/CACNA1B). Displays an analgesic potency similar to MVIIA in a range of acute and chronic pain models in rodents, but has less adverse effects compared with identical dosages of MVIIA injected intrathecally.[1]
References
- ↑ Wen L, Yang S, Qiao H, Liu Z, Zhou W, Zhang Y, Huang P. SO-3, a new O-superfamily conopeptide derived from Conus striatus, selectively inhibits N-type calcium currents in cultured hippocampal neurons. Br J Pharmacol. 2005 Jul;145(6):728-39. PMID:15880145 doi:http://dx.doi.org/0706223
