Structural highlights
Publication Abstract from PubMed
Micronemes, specialised organelles found in all apicomplexan parasites, secrete molecules that are essential for parasite attachment and invasion of host cells. EtMIC5 is one such microneme protein that contains eleven tandemly repeating modules. These modules have homology with the PAN module superfamily. Members of this family are found in blood clotting proteins, some growth factors and some nematode proteins. This paper presents the structure of the 9th PAN module in EtMIC5, determined using high resolution NMR. The structure shows similarities to and some differences from the N-terminal module of hepatocyte growth factor (HGF), the only previous member of the PAN family with known structure.
Solution structure of a PAN module from the apicomplexan parasite Eimeria tenella.,Brown PJ, Mulvey D, Potts JR, Tomley FM, Campbell ID J Struct Funct Genomics. 2003;4(4):227-34. PMID:15185963[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Brown PJ, Mulvey D, Potts JR, Tomley FM, Campbell ID. Solution structure of a PAN module from the apicomplexan parasite Eimeria tenella. J Struct Funct Genomics. 2003;4(4):227-34. PMID:15185963
