Formate dehydrogenase

Formate dehydrogenase (FDH) catalyzes the reversible two-electron oxidation of formate to bicarbonate. The product electron is donated to either NAD+ in NAD-dependent FDH or to Mo-dependent FDH where the electron is donated to a Fe₄S₄ center and then to cytochrome. The Mo-dependent FDH-H from E. coli contains SelCys, Mo, molybdopterin guanosine dinucleotide (MGD) cofactor and Fe₄S₄^[1].

• in NAD-dependent formate dehydrogenase (2nad). Water molecules shown as red spheres.
• .

3D structure of formate dehydrogenase

Formate dehydrogenase 3D structures