Structural highlights
5ms3 is a 1 chain structure with sequence from Human. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
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| Ligands: | |
| Gene: | KLK8, NRPN, PRSS19, TADG14, UNQ283/PRO322 (HUMAN) |
| Activity: | Kallikrein 8, with EC number 3.4.21.118 |
| Resources: | FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT |
Function
[KLK8_HUMAN] Serine protease which is capable of degrading a number of proteins such as casein, fibrinogen, kininogen, fibronectin and collagen type IV. Also cleaves L1CAM in response to increased neural activity. Induces neurite outgrowth and fasciculation of cultured hippocampal neurons. Plays a role in the formation and maturation of orphan and small synaptic boutons in the Schaffer-collateral pathway, regulates Schaffer-collateral long-term potentiation in the hippocampus and is required for memory acquisition and synaptic plasticity. Involved in skin desquamation and keratinocyte proliferation. Plays a role in the secondary phase of pathogenesis following spinal cord injury.[1]
See Also
References
- ↑ Rajapakse S, Ogiwara K, Takano N, Moriyama A, Takahashi T. Biochemical characterization of human kallikrein 8 and its possible involvement in the degradation of extracellular matrix proteins. FEBS Lett. 2005 Dec 19;579(30):6879-84. doi: 10.1016/j.febslet.2005.11.039. Epub , 2005 Dec 1. PMID:16337200 doi:http://dx.doi.org/10.1016/j.febslet.2005.11.039
