Structural highlights
Function
[NXF1_DROME] Mediates the export of the majority of mRNAs from the nucleus to the cytoplasm.[1] [2] [3] [NXT1_DROME] Stimulator of protein export for NES-containing proteins (By similarity). Plays a role in the nuclear export of mRNA (PubMed:14729961). Also plays a role in the nuclear export of U1 snRNA, tRNA, and mRNA (By similarity).[UniProtKB:Q9UKK6][4]
References
- ↑ Korey CA, Wilkie G, Davis I, Van Vactor D. small bristles is required for the morphogenesis of multiple tissues during Drosophila development. Genetics. 2001 Dec;159(4):1659-70. PMID:11779805
- ↑ Herold A, Klymenko T, Izaurralde E. NXF1/p15 heterodimers are essential for mRNA nuclear export in Drosophila. RNA. 2001 Dec;7(12):1768-80. PMID:11780633
- ↑ Wilkie GS, Zimyanin V, Kirby R, Korey C, Francis-Lang H, Van Vactor D, Davis I. Small bristles, the Drosophila ortholog of NXF-1, is essential for mRNA export throughout development. RNA. 2001 Dec;7(12):1781-92. PMID:11780634
- ↑ Forler D, Rabut G, Ciccarelli FD, Herold A, Kocher T, Niggeweg R, Bork P, Ellenberg J, Izaurralde E. RanBP2/Nup358 provides a major binding site for NXF1-p15 dimers at the nuclear pore complex and functions in nuclear mRNA export. Mol Cell Biol. 2004 Feb;24(3):1155-67. doi: 10.1128/mcb.24.3.1155-1167.2004. PMID:14729961 doi:http://dx.doi.org/10.1128/mcb.24.3.1155-1167.2004
