Structural highlights
Function
[ALBU_BOVIN] Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc.
Publication Abstract from PubMed
The medicinal gold(III) dithiocarbamato complex AuL12 forms a stable adduct with bovine serum albumin. The crystal structure reveals that a single gold(I) center is bound to Cys34, with the dithiocarbamato ligand being released. To the best of our knowledge, this is the first structure for a gold adduct of serum albumin.
Structural Characterization of a Gold/Serum Albumin Complex.,Pratesi A, Cirri D, Fregona D, Ferraro G, Giorgio A, Merlino A, Messori L Inorg Chem. 2019 Jul 30. doi: 10.1021/acs.inorgchem.9b01900. PMID:31361466[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Pratesi A, Cirri D, Fregona D, Ferraro G, Giorgio A, Merlino A, Messori L. Structural Characterization of a Gold/Serum Albumin Complex. Inorg Chem. 2019 Jul 30. doi: 10.1021/acs.inorgchem.9b01900. PMID:31361466 doi:http://dx.doi.org/10.1021/acs.inorgchem.9b01900
