Interleukin receptors (ILR) are cytokine receptor which are classified into type I, type II and others. ILR type I are cell surface receptors which recognize cytokines with four α-helical strands. ILR type II are similar to type I but lack the former’s signature sequence: WXSWS. Interleukin-1 receptor belongs to the ILR of immunoglobulin family. IL1R contains two types. Type I (IL1R1) binds interleukin-1 (IL1) transmitting its inflammatory effect. Interleukin-1 receptor type II (IL1R2) suppresses IL1 activity. Another suppressor of IL1R activity is the interleukin-1 receptor antagonist (IL1R1A).
3D structures of interleukin receptor
Interleukin receptor 3D structures
