6ky4

Structural highlights

Function

[SRX_ARATH] Contributes to oxidative stress resistance by reducing cysteine-sulfinic acid formed under exposure to oxidants in a peroxiredoxin. May catalyze the reduction in a multi-step process by acting both as a specific phosphotransferase and a thioltransferase. Required to switch on the antioxidant pathway to regenerate the oxidative damage. In mitochondrion, catalyzes the retroreduction of the inactive sulfinic form of atypical Prx IIF using thioredoxin as reducing agent.^{[1] [2]}

References

1. ↑ Rey P, Becuwe N, Barrault MB, Rumeau D, Havaux M, Biteau B, Toledano MB. The Arabidopsis thaliana sulfiredoxin is a plastidic cysteine-sulfinic acid reductase involved in the photooxidative stress response. Plant J. 2007 Feb;49(3):505-14. doi: 10.1111/j.1365-313X.2006.02969.x. Epub 2007 , Jan 1. PMID:17217469 doi:http://dx.doi.org/10.1111/j.1365-313X.2006.02969.x
2. ↑ Iglesias-Baena I, Barranco-Medina S, Lazaro-Payo A, Lopez-Jaramillo FJ, Sevilla F, Lazaro JJ. Characterization of plant sulfiredoxin and role of sulphinic form of 2-Cys peroxiredoxin. J Exp Bot. 2010 Mar;61(5):1509-21. doi: 10.1093/jxb/erq016. Epub 2010 Feb 22. PMID:20176891 doi:http://dx.doi.org/10.1093/jxb/erq016