Sandbox ggc6
From Proteopedia
Nucleosome with H4 histone interactions
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FunctionThe N-terminal tails of core histones in a nucleosome core particle (NCP) aid in a multitude of functions such as structural stability, thermal stability, and the stimulation of transcription binding factors.[3] ImportanceThe N-terminal tail interactions of the H4 histone are crucial in order to correctly fold the nucleosomes into compact units that can be used to form chromatin fibers. This interaction occurs on the G14 to R19 or K16 to N25 residues that reside on the N-terminal tail of H4 and the acidic patch of the neighboring nucleosome. [4] RelevanceThrough various observations, the scientists have presumed that the acetylation of the nucleosome itself is what regulates the decompaction of the higher-order chromatin structure, even in the absence of chromatin- associated factors. [5] Structural highlightsBelow are the various structural highlight of the H4-tetra-acetylated NCP: displays in green the molecule B which is composed of residues 1-20 while the color yellow represents the molecule F which highlights residues 1-15. show the H4 nucleosome in its unaltered state.
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