Overview
Riboswitches are metabolite-sensing-mRNAs that interact with small ligands and direct expression of the genes involved in their metabolism.
Structure
The adenine bound A-riboswitch complex adopts a tuning fork-like
compact fold (schematic in Figure 4A; structures in Figures 4B and 4C), where stem P1 forms the handle of the tuning fork, and stems P2 and P3, which form the prongs, are aligned parallel to each other and anchored at the tips through extensive interaction between their hairpin loops L2 and L3. The central internal bubble zippers up through stacked base triple alignments between the three junction-connecting segments, J1-2, J2-3, and J3-1, and two junctional base pairs of stem P1, thereby generating an adenine-sensing pocket within the resulting core segment of the RNA scaffold.
Relevance
Figures
Etc.
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