Function
4-hydroxy-2-methylbut-2-enyl diphosphate reductase (IspH or HMBPP reductase) is an containing protein. IspH converts 1-hydroxy-2-methylbut-2-enyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). IspH participates in isoprenoid biosynthesis. IspH is the last enzyme in the nonmevalonate pathway. [1]
Disease
IspH is involved in penicillin tolerance.
Structural highlights
- is shown.
- .
- Of note, .
- .
- . Water molecules are shown as red spheres.
- (PDB code 3szl).[2]
3D structures of 4-hydroxy-3-methylbut-2-enyl diphosphate reductase
4-hydroxy-3-methylbut-2-enyl diphosphate reductase 3D structures