Function
6-phosphogluconate dehydrogenase (6PGD) catalyzes the decarboxylation reduction of 6-phosphogluconate (6PG) to ribulose 5-phosphate and CO2. This reaction is part of the pentose phosphate pathway. NADP is a cofactor in this reaction and is converted to NADPH.[1]
- with Sheep 6-phosphogluconate dehydrogenase (PDB code 1pgo). Water molecules are shown as red spheres.
- .
Disease
6PGD deficiency is an autosomal hereditary disease which manifests itself by abnormal breakdown of red blood cells. Treatment involves avoidance of drugs or foods which can cause hemolysis.[2]
3D structures of 6-phosphogluconate dehydrogenase
6-phosphogluconate dehydrogenase 3D structures
