6hxr

Structural highlights

Function

[PAR16_HUMAN] Mono-ADP-ribosyltransferase targeting the karyopherin KPNB1. Plays a role in unfolded protein response (UPR), by ADP-ribosylating and activating EIF2AK3 and ERN1, two important UPR effectors.^{[1] [2]}

References

1. ↑ Jwa M, Chang P. PARP16 is a tail-anchored endoplasmic reticulum protein required for the PERK- and IRE1alpha-mediated unfolded protein response. Nat Cell Biol. 2012 Nov;14(11):1223-30. doi: 10.1038/ncb2593. Epub 2012 Oct 28. PMID:23103912 doi:http://dx.doi.org/10.1038/ncb2593
2. ↑ Di Paola S, Micaroni M, Di Tullio G, Buccione R, Di Girolamo M. PARP16/ARTD15 is a novel endoplasmic-reticulum-associated mono-ADP-ribosyltransferase that interacts with, and modifies karyopherin-ss1. PLoS One. 2012;7(6):e37352. doi: 10.1371/journal.pone.0037352. Epub 2012 Jun 11. PMID:22701565 doi:http://dx.doi.org/10.1371/journal.pone.0037352