Sandbox GGC12

Structure

The structure of the TBP has a pseudo-symmetry within its structure which contains two 88- amino acid repeats. This structure attaches to a DNA structure of deformity in the helix; the deformity is for the purpose of binding. The DNA structure's minor groove is open- wide to have complete access for the TBP to bind within it (2).

Function

The TATA-Binding protein, TBP, is a factor in the process of Transcription within Eukaryotes. This binding protein is a subunit in the family of TFIID. The function of the TBP is to bind to a DNA sequence which is the TATA box. This allows RNA Polymerase II to bind to the promoter. This is the beginning of the process of Transcription (3).

Relevance

The TATA-Binding Protein is relevant to everyday life because humans contain this specific protein as well with or without a promoter. This process is happening in multiple tissues and cells at a time (1).

Interesting Facts about the TBP

-The first ever for the TBP was found in fruit flies, specifically Drosophila flies.

-This is not the same idea in prokaryotes. Prokaryotes have a different concept because it is a Pribnow box instead of a TATA box (2).

-Another name for the TATA box is the Goldberg- Hogness box (1).

Structural highlights