Structural highlights
5w7l is a 2 chain structure with sequence from Camc1. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
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| Ligands: | , , , |
| Gene: | pglC, CCC13826_0450 (CAMC1) |
| Activity: | Undecaprenyl phosphate N,N'-diacetylbacillosamine 1-phosphate transferase, with EC number 2.7.8.36 |
| Resources: | FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT |
Publication Abstract from PubMed
Polyprenol phosphate phosphoglycosyl transferases (PGTs) catalyze the first membrane-committed step in assembly of essential glycoconjugates. Currently there is no structure-function information to describe how monotopic PGTs coordinate the reaction between membrane-embedded and soluble substrates. We describe the structure and mode of membrane association of PglC, a PGT from Campylobacter concisus. The structure reveals a unique architecture, provides mechanistic insight and identifies ligand-binding determinants for PglC and the monotopic PGT superfamily.
Membrane association of monotopic phosphoglycosyl transferase underpins function.,Ray LC, Das D, Entova S, Lukose V, Lynch AJ, Imperiali B, Allen KN Nat Chem Biol. 2018 May 16. pii: 10.1038/s41589-018-0054-z. doi:, 10.1038/s41589-018-0054-z. PMID:29769739[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Ray LC, Das D, Entova S, Lukose V, Lynch AJ, Imperiali B, Allen KN. Membrane association of monotopic phosphoglycosyl transferase underpins function. Nat Chem Biol. 2018 May 16. pii: 10.1038/s41589-018-0054-z. doi:, 10.1038/s41589-018-0054-z. PMID:29769739 doi:http://dx.doi.org/10.1038/s41589-018-0054-z
