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Function
Lysyl-tRNA synthetase (LysS) is a member of the class II aminoacyl-tRNA synthetases and catalyses the specific aminoacylation of tRNA(Lys). There are two different proteins that code for lysyl-tRNA synthase, LysS and LysU. The LysS is expressed under normal contionds, where the LysU is overexpressed in conditions like high temperature, anaerobiosis, low external pH, or the presence of leucine. [3] The source organism comes from Escherichia coli. The LysS is a protein that plays an important role in the translation of the genetic sequence. The LysS aids in an accurate translation of the mRNA. [4]
Disease
A mutation in the LysS has shown to have played a role in the reduction of the outer membrane vesiculation. [5] The LysS gene has been determined to coincide with the HerC gene.
Relevance
A defect in the translation of the genetic material from LysS would impact the functionality of the protein.
Structural highlights
The first interaction that leads to a reorganization of the active site is from the binding of the α amino group from the lysine and the carbonyl oxygen of gly216.
