| Structural highlights
5xjx is a 12 chain structure with sequence from Arath. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
| | Gene: | TMM, RLP17, At1g80080, F18B13.16 (ARATH), ERL1, At5g62230, MMI9.14 (ARATH) |
| Activity: | Non-specific serine/threonine protein kinase, with EC number 2.7.11.1 |
| Resources: | FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT |
Function
[TMM_ARATH] Promotes cell fate progression in stomatal development. In leaves, needed to correctly orient spacing divisions, to limit the number of asymmetric divisions in neighbor cells, and to promote the asymmetric (amplifying) divisions of meristemoids. In stems, promotes the conversion of meristemoids into guard mother cells (GMC) (PubMed:11090210, PubMed:12040198, PubMed:18979118). Positively regulates CAPRICE (CPC) expression in differentiating stomaless-forming cell files (PubMed:19513241). Forms constitutive complexes with ERECTA and ERL1 involved in the recognition of the stomatal regulatory peptides EPF1, EPF2 and EPFL9/STOMAGEN (PubMed:28536146). Modulates the activity of the ligand-receptor pairs EPF2-ERECTA and EPF1-ERL1 in stomatal development (PubMed:16002616, PubMed:22241782). Functions in a combinatorial specific manner with the ERECTA-family (ERf) receptor kinases in the regulation of the immune response (PubMed:27446127).[1] [2] [3] [4] [5] [6] [7] [8] [ERL1_ARATH] Receptor kinase that regulates inflorescence architecture and organ shape as well as stomatal patterning, including density and clustering, together with ER and ERL2. Redundantly involved with ER in procambial development regulation. Forms a functional ligand-receptor pair with EPF1 (AC Q8S8I4) (PubMed:22241782). Forms a constitutive complex with TMM involved in the recognition of the stomatal regulatory peptides EPF1, EPF2 and EPFL9/STOMAGEN (PubMed:28536146).[9] [10] [11] [12] [13] [14]
Publication Abstract from PubMed
Stomata are microscopic openings that allow for the exchange of gases between plants and the environment. In Arabidopsis, stomatal patterning is specified by the ERECTA family (ERf) receptor kinases (RKs), the receptor-like protein (RLP) TOO MANY MOUTHS (TMM), and EPIDERMAL PATTERNING FACTOR (EPF) peptides. Here we show that TMM and ER or ER-LIKE1 (ERL1) form constitutive complexes, which recognize EPF1 and EPF2, but the single ERfs do not. TMM interaction with ERL1 creates a binding pocket for recognition of EPF1 and EPF2, indicating that the constitutive TMM-ERf complexes function as the receptors of EPF1 and EPF2. EPFL9 competes with EPF1 and EPF2 for binding to the ERf-TMM complex. EPFL4 and EPFL6, however, are recognized by the single ERfs without the requirement of TMM. In contrast to EPF1,2, the interaction of EPFL4,6 with an ERf is greatly reduced in the presence of TMM. Taken together, our data demonstrate that TMM dictates the specificity of ERfs for the perception of different EPFs, thus functioning as a specificity switch for the regulation of the activities of ERfs.
A receptor-like protein acts as a specificity switch for the regulation of stomatal development.,Lin G, Zhang L, Han Z, Yang X, Liu W, Li E, Chang J, Qi Y, Shpak ED, Chai J Genes Dev. 2017 May 1;31(9):927-938. doi: 10.1101/gad.297580.117. Epub 2017 May, 23. PMID:28536146[15]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Geisler M, Nadeau J, Sack FD. Oriented asymmetric divisions that generate the stomatal spacing pattern in arabidopsis are disrupted by the too many mouths mutation. Plant Cell. 2000 Nov;12(11):2075-86. doi: 10.1105/tpc.12.11.2075. PMID:11090210 doi:http://dx.doi.org/10.1105/tpc.12.11.2075
- ↑ Nadeau JA, Sack FD. Control of stomatal distribution on the Arabidopsis leaf surface. Science. 2002 May 31;296(5573):1697-700. doi: 10.1126/science.1069596. PMID:12040198 doi:http://dx.doi.org/10.1126/science.1069596
- ↑ Shpak ED, McAbee JM, Pillitteri LJ, Torii KU. Stomatal patterning and differentiation by synergistic interactions of receptor kinases. Science. 2005 Jul 8;309(5732):290-3. doi: 10.1126/science.1109710. PMID:16002616 doi:http://dx.doi.org/10.1126/science.1109710
- ↑ Bhave NS, Veley KM, Nadeau JA, Lucas JR, Bhave SL, Sack FD. TOO MANY MOUTHS promotes cell fate progression in stomatal development of Arabidopsis stems. Planta. 2009 Jan;229(2):357-67. doi: 10.1007/s00425-008-0835-9. Epub 2008 Nov 1. PMID:18979118 doi:http://dx.doi.org/10.1007/s00425-008-0835-9
- ↑ Serna L. CAPRICE positively regulates stomatal formation in the Arabidopsis hypocotyl. Plant Signal Behav. 2008 Dec;3(12):1077-82. doi: 10.4161/psb.3.12.6254. PMID:19513241 doi:http://dx.doi.org/10.4161/psb.3.12.6254
- ↑ Lee JS, Kuroha T, Hnilova M, Khatayevich D, Kanaoka MM, McAbee JM, Sarikaya M, Tamerler C, Torii KU. Direct interaction of ligand-receptor pairs specifying stomatal patterning. Genes Dev. 2012 Jan 15;26(2):126-36. doi: 10.1101/gad.179895.111. Epub 2012 Jan, 12. PMID:22241782 doi:http://dx.doi.org/10.1101/gad.179895.111
- ↑ Jorda L, Sopena-Torres S, Escudero V, Nunez-Corcuera B, Delgado-Cerezo M, Torii KU, Molina A. ERECTA and BAK1 Receptor Like Kinases Interact to Regulate Immune Responses in Arabidopsis. Front Plant Sci. 2016 Jun 28;7:897. doi: 10.3389/fpls.2016.00897. eCollection, 2016. PMID:27446127 doi:http://dx.doi.org/10.3389/fpls.2016.00897
- ↑ Lin G, Zhang L, Han Z, Yang X, Liu W, Li E, Chang J, Qi Y, Shpak ED, Chai J. A receptor-like protein acts as a specificity switch for the regulation of stomatal development. Genes Dev. 2017 May 1;31(9):927-938. doi: 10.1101/gad.297580.117. Epub 2017 May, 23. PMID:28536146 doi:http://dx.doi.org/10.1101/gad.297580.117
- ↑ Shpak ED, Berthiaume CT, Hill EJ, Torii KU. Synergistic interaction of three ERECTA-family receptor-like kinases controls Arabidopsis organ growth and flower development by promoting cell proliferation. Development. 2004 Apr;131(7):1491-501. doi: 10.1242/dev.01028. Epub 2004 Feb 25. PMID:14985254 doi:http://dx.doi.org/10.1242/dev.01028
- ↑ Shpak ED, McAbee JM, Pillitteri LJ, Torii KU. Stomatal patterning and differentiation by synergistic interactions of receptor kinases. Science. 2005 Jul 8;309(5732):290-3. doi: 10.1126/science.1109710. PMID:16002616 doi:http://dx.doi.org/10.1126/science.1109710
- ↑ Pillitteri LJ, Bemis SM, Shpak ED, Torii KU. Haploinsufficiency after successive loss of signaling reveals a role for ERECTA-family genes in Arabidopsis ovule development. Development. 2007 Sep;134(17):3099-109. doi: 10.1242/dev.004788. Epub 2007 Jul, 25. PMID:17652352 doi:http://dx.doi.org/10.1242/dev.004788
- ↑ Lee JS, Kuroha T, Hnilova M, Khatayevich D, Kanaoka MM, McAbee JM, Sarikaya M, Tamerler C, Torii KU. Direct interaction of ligand-receptor pairs specifying stomatal patterning. Genes Dev. 2012 Jan 15;26(2):126-36. doi: 10.1101/gad.179895.111. Epub 2012 Jan, 12. PMID:22241782 doi:http://dx.doi.org/10.1101/gad.179895.111
- ↑ Uchida N, Tasaka M. Regulation of plant vascular stem cells by endodermis-derived EPFL-family peptide hormones and phloem-expressed ERECTA-family receptor kinases. J Exp Bot. 2013 Dec;64(17):5335-43. doi: 10.1093/jxb/ert196. Epub 2013 Jul 23. PMID:23881395 doi:http://dx.doi.org/10.1093/jxb/ert196
- ↑ Lin G, Zhang L, Han Z, Yang X, Liu W, Li E, Chang J, Qi Y, Shpak ED, Chai J. A receptor-like protein acts as a specificity switch for the regulation of stomatal development. Genes Dev. 2017 May 1;31(9):927-938. doi: 10.1101/gad.297580.117. Epub 2017 May, 23. PMID:28536146 doi:http://dx.doi.org/10.1101/gad.297580.117
- ↑ Lin G, Zhang L, Han Z, Yang X, Liu W, Li E, Chang J, Qi Y, Shpak ED, Chai J. A receptor-like protein acts as a specificity switch for the regulation of stomatal development. Genes Dev. 2017 May 1;31(9):927-938. doi: 10.1101/gad.297580.117. Epub 2017 May, 23. PMID:28536146 doi:http://dx.doi.org/10.1101/gad.297580.117
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