Structural highlights
Function
[ACTB_XENLA] Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.[UniProtKB:P60709] [TBG1_XENLA] Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome, suggesting that it is involved in the minus-end nucleation of microtubule assembly. [A0A1L8HGZ5_XENLA] Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome.[RuleBase:RU363050] [Q642S3_XENLA] Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome.[RuleBase:RU363050]
