2c47

Structural highlights

Function

[KC1G2_HUMAN] Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling (By similarity). Phosphorylates COL4A3BP/CERT, MTA1 and SMAD3. Involved in brain development and vesicular trafficking and neurotransmitter releasing from small synaptic vesicles. Regulates fast synaptic transmission mediated by glutamate. SMAD3 phosphorylation promotes its ligand-dependent ubiquitination and subsequent proteasome degradation, thus inhibiting SMAD3-mediated TGF-beta responses. Hyperphosphorylation of the serine-repeat motif of COL4A3BP/CERT leads to its inactivation by dissociation from the Golgi complex, thus down-regulating ER-to-Golgi transport of ceramide and sphingomyelin synthesis.^{[1] [2] [3] [4]}

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

• Casein kinase 3D structures

References

1. ↑ Yinan M, Yu Q, Zhiyue C, Jianjun L, Lie H, Liping Z, Jianhui Z, Fang S, Dingfang B, Qing L, Xiru W. Polymorphisms of casein kinase I gamma 2 gene associated with simple febrile seizures in Chinese Han population. Neurosci Lett. 2004 Sep 16;368(1):2-6. PMID:15342122 doi:http://dx.doi.org/10.1016/j.neulet.2004.06.054
2. ↑ Mishra SK, Yang Z, Mazumdar A, Talukder AH, Larose L, Kumar R. Metastatic tumor antigen 1 short form (MTA1s) associates with casein kinase I-gamma2, an estrogen-responsive kinase. Oncogene. 2004 May 27;23(25):4422-9. PMID:15077195 doi:http://dx.doi.org/10.1038/sj.onc.1207569
3. ↑ Guo X, Waddell DS, Wang W, Wang Z, Liberati NT, Yong S, Liu X, Wang XF. Ligand-dependent ubiquitination of Smad3 is regulated by casein kinase 1 gamma 2, an inhibitor of TGF-beta signaling. Oncogene. 2008 Dec 11;27(58):7235-47. doi: 10.1038/onc.2008.337. Epub 2008 Sep, 15. PMID:18794808 doi:http://dx.doi.org/10.1038/onc.2008.337
4. ↑ Tomishige N, Kumagai K, Kusuda J, Nishijima M, Hanada K. Casein kinase I{gamma}2 down-regulates trafficking of ceramide in the synthesis of sphingomyelin. Mol Biol Cell. 2009 Jan;20(1):348-57. doi: 10.1091/mbc.E08-07-0669. Epub 2008 Nov, 12. PMID:19005213 doi:http://dx.doi.org/10.1091/mbc.E08-07-0669