6u6v

Structural highlights

Function

[VISTA_HUMAN] Immunoregulatory receptor which inhibits the T-cell response (PubMed:24691993). May promote differentiation of embryonic stem cells, by inhibiting BMP4 signaling (By similarity). May stimulate MMP14-mediated MMP2 activation (PubMed:20666777).[UniProtKB:Q9D659]^{[1] [2]}

References

1. ↑ Sakr MA, Takino T, Domoto T, Nakano H, Wong RW, Sasaki M, Nakanuma Y, Sato H. GI24 enhances tumor invasiveness by regulating cell surface membrane-type 1 matrix metalloproteinase. Cancer Sci. 2010 Nov;101(11):2368-74. doi: 10.1111/j.1349-7006.2010.01675.x. PMID:20666777 doi:http://dx.doi.org/10.1111/j.1349-7006.2010.01675.x
2. ↑ Lines JL, Pantazi E, Mak J, Sempere LF, Wang L, O'Connell S, Ceeraz S, Suriawinata AA, Yan S, Ernstoff MS, Noelle R. VISTA is an immune checkpoint molecule for human T cells. Cancer Res. 2014 Apr 1;74(7):1924-32. doi: 10.1158/0008-5472.CAN-13-1504. PMID:24691993 doi:http://dx.doi.org/10.1158/0008-5472.CAN-13-1504