Function
Muscarinic acetylcholine receptors (mAChR) contain 5 subtypes M1-M5. Subtypes M1,M3,M5 activate phospholipase C which leads to activation of protein kinase C. M2 and M4 inhibit adenylyl cyclase activity and activate G protein-gated potassium channels[1]. mAChRs belong to the family of rhodopsin-like G protein coupled seven transmembrane helix receptors and perform various non-neuronal functions[2].
Disease
mAChR M1 agonists are developed for treatment of Alzheimer disease[3]. M2 antagonists are developed for treatment of Alzheimer disease and M3 antagonists for treatment of overactive bladder and chronic obstructive pulmonary disease[4]
Structural highlights
3D Structures of muscarinic acetylcholine receptors
Updated on 08-January-2020
