6ucc

Structural highlights

Function

[PACRG_HUMAN] Suppresses cell death induced by accumulation of unfolded Pael receptor (Pael-R, a substrate of Parkin). Facilitates the formation of inclusions consisting of Pael-R, molecular chaperones, protein degradation molecules and itself when proteasome is inhibited. May play an important role in the formation of Lewy bodies and protection of dopaminergic neurons against Parkinson disease.^[1] [MEIG1_HUMAN] Essential for spermiogenesis.

References

1. ↑ Imai Y, Soda M, Murakami T, Shoji M, Abe K, Takahashi R. A product of the human gene adjacent to parkin is a component of Lewy bodies and suppresses Pael receptor-induced cell death. J Biol Chem. 2003 Dec 19;278(51):51901-10. Epub 2003 Oct 7. PMID:14532270 doi:http://dx.doi.org/10.1074/jbc.M309655200