6j94

Structural highlights

Function

[LUT5_ARATH] Heme-containing cytochrome P450 involved in the biosynthesis of xanthophylls. Specific for beta-ring hydroxylation of alpha- and beta-carotene. Has also a low activity toward the epsilon-rings of alpha-carotene. The beta-ring of alpha-carotene is the preferred substrate in planta.^{[1] [2] [3]}

References

1. ↑ Kim J, DellaPenna D. Defining the primary route for lutein synthesis in plants: the role of Arabidopsis carotenoid beta-ring hydroxylase CYP97A3. Proc Natl Acad Sci U S A. 2006 Feb 28;103(9):3474-9. doi:, 10.1073/pnas.0511207103. Epub 2006 Feb 21. PMID:16492736 doi:http://dx.doi.org/10.1073/pnas.0511207103
2. ↑ Fiore A, Dall'osto L, Fraser PD, Bassi R, Giuliano G. Elucidation of the beta-carotene hydroxylation pathway in Arabidopsis thaliana. FEBS Lett. 2006 Aug 21;580(19):4718-22. doi: 10.1016/j.febslet.2006.07.055. Epub , 2006 Jul 26. PMID:16890225 doi:http://dx.doi.org/10.1016/j.febslet.2006.07.055
3. ↑ Kim J, Smith JJ, Tian L, Dellapenna D. The evolution and function of carotenoid hydroxylases in Arabidopsis. Plant Cell Physiol. 2009 Mar;50(3):463-79. doi: 10.1093/pcp/pcp005. Epub 2009 Jan, 15. PMID:19147649 doi:http://dx.doi.org/10.1093/pcp/pcp005