Structural highlights
Disease
[ACTH_HUMAN] Myopathic intestinal pseudoobstruction;Megacystis-microcolon-intestinal hypoperistalsis syndrome;Familial visceral myopathy. The disease is caused by mutations affecting the gene represented in this entry.
Function
[SETD3_HUMAN] Histone methyltransferase that methylates 'Lys-36' of histone H3 (H3K36me). H3 'Lys-36' methylation represents a specific tag for epigenetic transcriptional activation (By similarity). [ACTH_HUMAN] Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.