6jbc

Structural highlights

Function

[POK_THEKO] Phosphorylates (R)-pantoate to form (R)-4-phosphopantoate in the CoA biosynthesis pathway (PubMed:19666462, PubMed:22865846). Displays broad nucleotide specificity and utilizes ATP, GTP, UTP, and CTP with comparable catalytic efficiencies (PubMed:22865846).^{[1] [2]}

References

1. ↑ Yokooji Y, Tomita H, Atomi H, Imanaka T. Pantoate kinase and phosphopantothenate synthetase, two novel enzymes necessary for CoA biosynthesis in the Archaea. J Biol Chem. 2009 Oct 9;284(41):28137-45. doi: 10.1074/jbc.M109.009696. Epub 2009, Aug 7. PMID:19666462 doi:http://dx.doi.org/10.1074/jbc.M109.009696
2. ↑ Tomita H, Yokooji Y, Ishibashi T, Imanaka T, Atomi H. Biochemical characterization of pantoate kinase, a novel enzyme necessary for coenzyme A biosynthesis in the Archaea. J Bacteriol. 2012 Oct;194(19):5434-43. doi: 10.1128/JB.06624-11. Epub 2012 Aug 3. PMID:22865846 doi:http://dx.doi.org/10.1128/JB.06624-11