Structural highlights
6j7x is a 3 chain structure with sequence from Human. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
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| Ligands: | , |
| Gene: | PTAR1 (HUMAN), RABGGTB, GGTB (HUMAN), YKT6 (HUMAN) |
| Activity: | Protein geranylgeranyltransferase type II, with EC number 2.5.1.60 |
| Resources: | FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT |
Function
[YKT6_HUMAN] Vesicular soluble NSF attachment protein receptor (v-SNARE) mediating vesicle docking and fusion to a specific acceptor cellular compartment. Functions in endoplasmic reticulum to Golgi transport; as part of a SNARE complex composed of GOSR1, GOSR2 and STX5. Functions in early/recycling endosome to TGN transport; as part of a SNARE complex composed of BET1L, GOSR1 and STX5. Has a S-palmitoyl transferase activity.[1] [2] [PGTB2_HUMAN] Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of Rab proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX, such as RAB1A, RAB3A, RAB5A and RAB7A.
References
- ↑ Tai G, Lu L, Wang TL, Tang BL, Goud B, Johannes L, Hong W. Participation of the syntaxin 5/Ykt6/GS28/GS15 SNARE complex in transport from the early/recycling endosome to the trans-Golgi network. Mol Biol Cell. 2004 Sep;15(9):4011-22. Epub 2004 Jun 23. PMID:15215310 doi:http://dx.doi.org/10.1091/mbc.E03-12-0876
- ↑ McNew JA, Sogaard M, Lampen NM, Machida S, Ye RR, Lacomis L, Tempst P, Rothman JE, Sollner TH. Ykt6p, a prenylated SNARE essential for endoplasmic reticulum-Golgi transport. J Biol Chem. 1997 Jul 11;272(28):17776-83. doi: 10.1074/jbc.272.28.17776. PMID:9211930 doi:http://dx.doi.org/10.1074/jbc.272.28.17776
