User:Nikhil Malvankar/Geobacter pilus structure and function

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Interactive 3D Complement in Proteopedia

Structure of novel pili evolved for extracellular translocation of microbial nanowires

Yangqi Gu, Vishok Srikanth, Ruchi Jain, Aldo I. Salazar-Morales, J. Patrick O'Brien, Sophia M. Yi, Rajesh K. Soni, Fadel A. Samatey, Sibel Ebru Yalcin, and Nikhil S. Malvankar. (journal article link here) (2020). (DOI link here)

Contents 1 Molecular Tour 2 Download 2.1 Animations for Powerpoint 3 See Also 4 Notes & References

Molecular Tour

spinqualitylabelsall models Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image Our electron cryomicroscopic structure of Geobacter sulfurreducens pili reveals them to be composed of a core of PilA-N coated with an outer surface layer of PilA-C (. Here is a (front half hidden). The C-termini of PilA-N in PilA-C. The filament is assembled from . Dimer : PilA-N consists of two alpha helices, while PilA-C includes a 3-stranded beta sheet. The C-terminal protrusion of PilA-N is held between two flaps of PilA-C. These flaps might be open before PilA-N arrives to form a dimer, reminiscent of the flaps of HIV protease[1].

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See Also

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Notes & References

1. ↑ Hornak V, Okur A, Rizzo RC, Simmerling C. HIV-1 protease flaps spontaneously open and reclose in molecular dynamics simulations. Proc Natl Acad Sci U S A. 2006 Jan 24;103(4):915-20. doi:, 10.1073/pnas.0508452103. Epub 2006 Jan 17. PMID:16418268 doi:http://dx.doi.org/10.1073/pnas.0508452103