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Sonic Hedgehog Protein (1vhh)
Sonic Hedgehog Protien (SHH) is a very neat signaling protein that is not very fast like the name suggests
Function
Signaling, development, differentiation
Disease
Nonfunctioning/defective SHH can lead to a plethora of protopathic developmental ailments including microphthalmia, holoprosencephaly, and triphalangeal thumb-polysyndactyly syndrome. SHH is particularly interesting due to its role in cell division specifically of stem cells (in a fully developed human). As a result SHH has been directly tied to the cause of some cancers and the target of some anticancer drugs.
Relevance
Sonic hedgehog is very relevant
Structural highlights
its cool
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