General Function
Trichosurin is a protein from the milk whey of the common brushtail possum Trichosurus vulpecula [1]. It is a lipocalin, which is an extracellular protein (17–25 kDa) that can bind and transport small lipophilic molecules [2].
Structure
Trichosurin follows the general lipocalin fold pattern, with eight-stranded anti-parallel β-barrel, and the structure then forms a dimer with another identical β-barrel [3].
Structure and Function
The binding site is found in the centre of the β-barrel and can be occupied by water and isopropanol molecules from the corresponding crystallization medium [4]. The protein was also crystallized with 2-naphthol and 4-ethylphenol that were bound in the centre of the β-barrel. The presence of such phenolic compounds provides clues to the function of trichosurin- .
Evolutionarily Related Proteins
Relevance
Trichosurin is an important marsupial milk protein, is highly conserved across metatherians. The opossum,
Available Structures
References
- ↑ Watson RP, Demmer J, Baker EN, Arcus VL. Three-dimensional structure and ligand binding properties of trichosurin, a metatherian lipocalin from the milk whey of the common brushtail possum Trichosurus vulpecula. Biochem J. 2007 Nov 15;408(1):29-38. PMID:17685895 doi:10.1042/BJ20070567
- ↑ Watson RP, Demmer J, Baker EN, Arcus VL. Three-dimensional structure and ligand binding properties of trichosurin, a metatherian lipocalin from the milk whey of the common brushtail possum Trichosurus vulpecula. Biochem J. 2007 Nov 15;408(1):29-38. PMID:17685895 doi:10.1042/BJ20070567
- ↑ Watson RP, Demmer J, Baker EN, Arcus VL. Three-dimensional structure and ligand binding properties of trichosurin, a metatherian lipocalin from the milk whey of the common brushtail possum Trichosurus vulpecula. Biochem J. 2007 Nov 15;408(1):29-38. PMID:17685895 doi:10.1042/BJ20070567
- ↑ Watson RP, Demmer J, Baker EN, Arcus VL. Three-dimensional structure and ligand binding properties of trichosurin, a metatherian lipocalin from the milk whey of the common brushtail possum Trichosurus vulpecula. Biochem J. 2007 Nov 15;408(1):29-38. PMID:17685895 doi:10.1042/BJ20070567
[1]
Additional Resources
