1ao7
From Proteopedia
COMPLEX BETWEEN HUMAN T-CELL RECEPTOR, VIRAL PEPTIDE (TAX), AND HLA-A 0201
Overview
Recognition by a T-cell antigen receptor (TCR) of peptide complexed with a major histocompatibility complex (MHC) molecule occurs through variable loops in the TCR structure which bury almost all the available peptide and a much larger area of the MHC molecule. The TCR fits diagonally across the MHC peptide-binding site in a surface feature common to all class I and class II MHC molecules, providing evidence that the nature of binding is general. A broadly applicable binding mode has implications for the mechanism of repertoire selection and the magnitude of alloreactions.
About this Structure
1AO7 is a Protein complex structure of sequences from Homo sapiens and Human t-lymphotropic virus 1. Full crystallographic information is available from OCA.
Reference
Structure of the complex between human T-cell receptor, viral peptide and HLA-A2., Garboczi DN, Ghosh P, Utz U, Fan QR, Biddison WE, Wiley DC, Nature. 1996 Nov 14;384(6605):134-41. PMID:8906788 Page seeded by OCA on Fri May 2 10:30:10 2008
