From Proteopedia

Mitochondrial Calcium Uniporter, E. coli

spinqualitylabelsall models Mitochondrial calcium uniporter 6Dt0 Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image scene= Contents 1 Introduction 1.1 selectivity pore 2 Disease 3 Relevance 4 Structural highlights Introduction selectivity pore Figure 1 Disease Relevance Calcium signaling Structural highlights The MCU is a tetrameric truncated pyramid with only a single strong binding, site located in the selectivity pore, near the surface of the mitochondrial membrane. The is located in the , in TM2 while TM 1 surrounds the pore. Activity of the uniporter is dependent on membrane potential and calcium concentration. Calcium from the cytoplasm entrees the mitochondrial innermemnrane space through the mitochondrial membrane and is passed to the mitochondrial matrix via the MCU. Figure 2

References

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1. ↑ Ransey E, Paredes E, Dey SK, Das SR, Heroux A, Macbeth MR. Crystal structure of the Entamoeba histolytica RNA lariat debranching enzyme EhDbr1 reveals a catalytic Zn(2+) /Mn(2+) heterobinucleation. FEBS Lett. 2017 Jul;591(13):2003-2010. doi: 10.1002/1873-3468.12677. Epub 2017, Jun 14. PMID:28504306 doi:http://dx.doi.org/10.1002/1873-3468.12677
2. ↑ Yoo J, Wu M, Yin Y, Herzik MA Jr, Lander GC, Lee SY. Cryo-EM structure of a mitochondrial calcium uniporter. Science. 2018 Jun 28. pii: science.aar4056. doi: 10.1126/science.aar4056. PMID:29954988 doi:http://dx.doi.org/10.1126/science.aar4056

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