Background
The ABCG2 multidrug transporter is a membrane protein from the ATP-binding cassette (ABC) transporter family, specifically the G-subfamily. Also know as the breast cancer resistance protein (BCRP), ABCG2 has physiological roles in various tissue cells including the mammary gland and the blood-brain, blood-testis, and maternal-fetal barriers.[1] ABCG2 protects cells by exporting xenobiotic molecules out of the cell using ATP hydrolysis. ABCG2 also affects the pharmacokinetics of many drugs and contributes to multidrug resistance.[2]
Structural highlights
Overall 3D Structure
NBD - binding site for atp Homodimer
ATP Bound and Unbound Conformations
Cavities and Lysine Plug
Disease
Cancer
ABCG2 contributes to multidrug resistance in cancer cells by exporting anti-tumor drugs out of cells which introduces an obstacle in cancer treatment.[1]
brief description of the cancer genes listed in the papers (papers talk about how some cancers had more expression of abcg2 genes)
ABCG2 as a Target for Inhibition
Talk about how and why it would be a good target for the treatment of cancer and include paper talking about inhibition of it
