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Contents 1 Mitochondrial Calcium Uniporter, E. coli 1.1 Introduction 1.1.1 selectivity pore 1.2 Disease 1.3 Relevance 1.4 Structural highlights and mechanism

Mitochondrial Calcium Uniporter, E. coli

Introduction

selectivity pore

Disease

Relevance

Calcium signaling

Structural highlights and mechanism

The MCU is a dimer of dimers, described as tetrameric truncated pyramid. The uniporter has only a single strong binding site located in the selectivity pore with specificity for Calcium, near the surface of the inner mitochondrial membrane. ^{[1] [2] [1]}