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2qu4
From Proteopedia
Revision as of 16:58, 10 April 2020 by OCA (Talk | contribs)
2qu4 is a 1 chain structure with sequence from Escherichia coli. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
[PARM_ECOLX] Involved in the control of plasmid partition. Required for the accurate segregation of the plasmid.
Evolutionary Conservation
Checkto colour the structure by Evolutionary Conservation, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
Publication Abstract from PubMed
Bacterial ParM is a homolog of eukaryotic actin and is involved in moving plasmids so that they segregate properly during cell division. Using cryo-EM and three-dimensional reconstruction, we show that ParM filaments have a different structure from F-actin, with very different subunit-subunit interfaces. These interfaces result in the helical handedness of the ParM filament being opposite to that of F-actin. Like F-actin, ParM filaments have a variable twist, and we show that this involves domain-domain rotations within the ParM subunit. The present results yield new insights into polymorphisms within F-actin, as well as the evolution of polymer families.
The structure of bacterial ParM filaments.,Orlova A, Garner EC, Galkin VE, Heuser J, Mullins RD, Egelman EH Nat Struct Mol Biol. 2007 Oct;14(10):921-6. Epub 2007 Sep 16. PMID:17873883[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
