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Function
Tailspike protein (TSP) of bacteriophage P22 is a trimeric protein which serves as the receptor-binding protein of the bacteriophage to its bacterial host[1].
Disease
Relevance
Structural highlights
The N-terminal domain (NTD) (residues 1-108) of TSP is responsible for the attachment
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3D structures of tailspike protein
2xc1 - P22TSP - bacteriophage P22
1lkt - P22TSP NTD
2vky - P22TSP NTD/isoleucine zipper
2vnl - P22TSP NTD/isoleucine zipper (mutant)
1tyv, 1tyu, 1tyx, 1tyw, 2vfm, 1tsp - P22TSP CTD
1qq1, 1qrc, 1qrb, 2vfp, 2vfo, 2vfq, 1qa3, 1qa2, 1qa1, 2vfn, 1clw - P22TSP CTD 109-667 (mutant)
3th0 - P22TSP CTD + octasaccharide
2vji - HK620TSP NTD - bacteriophage HK620
4avz, 4xon, 4xqf, 4xlc, 4xl9, 4xkv, 4xlh, 4xnf, 4xn0 - HK520TSP CTD (mutant)
2x85, 2vjj, 2x6x - HK520TSP CTD + hexasaccharide
2x6w, 2x6y, 4xla, 5xop, 5xor, 4xr6, 4yej, 4yel, 4xle, 4xlf, 4xkw, 4xm3, 4xmy, 4xn3, 4xot - HK520TSP CTD (mutant) + polysaccharide
2vbe - TSP CTD - bacteriophage SFVI
2vbk - SF6TSP CTD - bacteriophage SF6
2vbm - SF6TSP CTD + tetrasaccharide
6nw9, 5w6f - CBA120TSP3 - bacteriophage CBA120
5w6h - CBA120TSP4 active domain 344-1056
6f7d - SF6TSP CTD - bacteriophage DET7
5js4 - TSP - bacteriophage PHIAB6
References
- ↑ Williams J, Venkatesan K, Ayariga JA, Jackson D, Wu H, Villafane R. A genetic analysis of an important hydrophobic interaction at the P22 tailspike protein N-terminal domain. Arch Virol. 2018 Jun;163(6):1623-1633. doi: 10.1007/s00705-018-3777-y. Epub 2018 , Mar 2. PMID:29500571 doi:http://dx.doi.org/10.1007/s00705-018-3777-y
