Sandbox Reserved 895

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This Sandbox is Reserved from Jan 13 through July 31, 2020 for use in the course Protein Structure in Drug Discovery taught by Karen C. Glass at the ACPHS, Colchester, United States. This reservation includes Sandbox Reserved 895 through Sandbox Reserved 901.
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1. Introduction

In humans the vertebrate vision is maintained by a chemical process known as the retinoid (visual) cycle. This cycle is a complex enzymatic pathway that operates within the retina to regenerate a key visual chromophore known as 11-cis-retinal. The enzyme responsible for regenerating the key visual chromophore, 11-cis-retinal is a microsomal membrane protein retinal pigment epithelium 65 also known as RPE65. The RPE65 enzyme catalyzes the chemical conversion of all-trans-retinyl ester (or all-trans-retinyl palmityl ester) to 11-cis-retinol within the human retinal pigment epithelium (hRPE). [1]

RPE65 is located within the hRPE cells located in the back of the eye. The human retinal pigment epithelium is responsible for regulating the nourishment of the retina. Since the retinoid (visual) cycle requires the incorporation of light into catalyzing chemical reactions, hRPE cells are light sensitive.


References

  1. ↑ doi: https://dx.doi.org/10.1073/pnas.0906600106
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