Overview
Histone-lysine N-methyltransferase 2A (KMT2A) which is also known as acute lymphoblastic leukemia 1 (ALL-1) is an enzyme that in humans is encoded by the KMT2A gene. KMT2A is a histone methyltransferase is a positive global regulator of gene transcription. The protein comes from a group of histone-modifying enzymes comprising transactivation domain 9aaTAD and is involved in the epigenetic maintenance of transcriptional memory [1] .
Function
Disease
Relevance
Structural highlights
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References
- ↑ Fyodorov DV, Kadonaga JT. Binding of Acf1 to DNA involves a WAC motif and is important for ACF-mediated chromatin assembly. Mol Cell Biol. 2002 Sep;22(18):6344-53. PMID:12192034
