Structural highlights
Publication Abstract from PubMed
Histo-blood group antigens (HBGAs) are important binding factors for norovirus infections. We show that two human milk oligosaccharides, 2' -fucosyllactose (2' FL) and 3-fucosyllactose (3FL), could block norovirus from binding to surrogate HBGA samples. We found that 2' FL and 3FL bound at the equivalent HBGA pocket on the norovirus capsid using X-ray crystallography. Our data revealed that 2' FL and 3FL structurally mimic HBGAs. These results suggest that 2' FL and 3FL might act as natural-occurring decoys in humans.
Structural Basis for Norovirus Inhibition by Human Milk Oligosaccharides.,Weichert S, Koromyslova A, Singh BK, Hansman S, Jennewein S, Schroten H, Hansman GS J Virol. 2016 Feb 17. pii: JVI.03223-15. PMID:26889023[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Weichert S, Koromyslova A, Singh BK, Hansman S, Jennewein S, Schroten H, Hansman GS. Structural Basis for Norovirus Inhibition by Human Milk Oligosaccharides. J Virol. 2016 Feb 17. pii: JVI.03223-15. PMID:26889023 doi:http://dx.doi.org/10.1128/JVI.03223-15
