1bg3

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Image:1bg3.gif

Template:STRUCTURE 1bg3

RAT BRAIN HEXOKINASE TYPE I COMPLEX WITH GLUCOSE AND INHIBITOR GLUCOSE-6-PHOSPHATE


Overview

We have determined the structures of the glucose-6-phosphate (G6P)-inhibitable 100,000 Mr Type I hexokinase from rat and the G6P-sensitive 50,000 Mr hexokinase from Schistosoma mansoni at a resolution of 2.8 and 2.6 A respectively. The structures define the glucose and G6P binding sites in these enzymes, suggest the mechanisms of intradomain G6P inhibition and activity loss in the Type I hexokinase N-terminal half, and reveal the structure of the membrane targeting motif that integrates the Type I hexokinase into the outer mitochondrial membrane.

About this Structure

1BG3 is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

The structure of mammalian hexokinase-1., Mulichak AM, Wilson JE, Padmanabhan K, Garavito RM, Nat Struct Biol. 1998 Jul;5(7):555-60. PMID:9665168 Page seeded by OCA on Fri May 2 11:28:11 2008

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