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Publication Abstract from PubMed

Human SIRT7 is an NAD+ dependent deacetylase which belongs to sirtuin family of proteins. SIRT7, like other sirtuins has conserved catalytic domain and is flanked by N- and C- terminal domains reported to play vital functional roles. Here, we report the crystal structure of the N-terminal domain of human SIRT7 (SIRT7NTD ) at 2.3 A resolution as MBP-SIRT7NTD fusion protein. SIRT7NTD adopts three-helical domain architecture and comparative structural analyses suggest similarities to some DNA binding motifs and transcription regulators. We also report here the importance of N- and C-terminal domains in soluble expression of SIRT7. This article is protected by copyright. All rights reserved.

Crystal structure of the N-terminal domain of human SIRT7 reveals a three-helical domain architecture.,Priyanka A, Solanki V, Parkesh R, Thakur KG Proteins. 2016 Jun 10. doi: 10.1002/prot.25085. PMID:27287224^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.