Structural highlights
Function
[MIA_HUMAN] Elicits growth inhibition on melanoma cells in vitro as well as some other neuroectodermal tumors, including gliomas.
Publication Abstract from PubMed
Melanoma inhibitory activity (MIA), an extracellular protein highly expressed by malignant melanoma cells, plays an important functional role in melanoma development, progression, and metastasis. After its secretion, MIA directly interacts with extracellular matrix proteins, such as fibronectin (FN). By this mechanism, MIA actively facilitates focal cell detachment from surrounding structures and strongly promotes tumour cell invasion and migration. Hence, the molecular understanding of MIA's function provides a promising target for the development of new strategies in malignant melanoma therapy. Here, we describe for the first time the discovery of small molecules that are able to disrupt the MIA-FN complex by selectively binding to a new druggable pocket, which we could identify on MIA by structural analysis and fragment-based screening. Our findings may inspire novel drug discovery efforts aiming at a therapeutically effective treatment of melanoma by targeting MIA.
Small Molecules Antagonise the MIA-Fibronectin Interaction in Malignant Melanoma.,Yip KT, Zhong XY, Seibel N, Putz S, Autzen J, Gasper R, Hofmann E, Scherkenbeck J, Stoll R Sci Rep. 2016 May 6;6:25119. doi: 10.1038/srep25119. PMID:27151361[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Yip KT, Zhong XY, Seibel N, Putz S, Autzen J, Gasper R, Hofmann E, Scherkenbeck J, Stoll R. Small Molecules Antagonise the MIA-Fibronectin Interaction in Malignant Melanoma. Sci Rep. 2016 May 6;6:25119. doi: 10.1038/srep25119. PMID:27151361 doi:http://dx.doi.org/10.1038/srep25119
