WWP2

From Proteopedia

proteopedia linkproteopedia link

Contents 1 Introduction 2 Structure 3 Function 4 Disease 5 Relevance 6 Structural highlights 7 References

Introduction

WWP2 is a type of ubiquitin protein ligase. More specifically, it is a member of the Homologous to the E6-AP Carboxyl Terminus (HECT) E3 Ligases family which accept a ubiquitin molecule from an enzyme upstream in the ubiquitination pathway and transfer the ubiquitin to a target signaling molecule or transcription factor. The thioester bond formation between an active site Cystine on HECT E3 Ligases and ubiquitin differentiates this family of enzymes from the more abundant RING family of ubiquitin ligases which do not covalently bond to the ubiquitin ligand. ---

Structure

spinqualitylabelsall models WWP2 Ubiquitin Ligase Full-length Structure (PDB entry 5TJ8) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image Green link for for Scene F1 17-142 is 302-361 is WW1 and WW2 361-407 is 2,3 Linker 407-477 is WW3 and WW4 489-870 is

Function

Disease

Relevance

Structural highlights

References